Enzymology & inhibitor characterization
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Enzymology plays an important role in the drug discovery. Parameters such as Ki
is a key to understand SAR and mechanism of inhibition. After rapid progress in the
last a few decades, enzymology has become a relatively mature area now. Our
well-trained and highly experienced enzymologists have worked on various enzymes
for many years in both academic and industry settings. We provide following services
and contract research
- basic properties of an enzyme: Km, Kcat and Vmax
- inhibitor characterization,
IC50 and Ki determination
mode of inhibition ( competitive, non-competitive or un-competitive)
- inhibitor binding to enzyme: Kd, kon and koff
- slow and tight binding inhibitors
- inhibitor binding site identification and characterization
mutation
competition
chemical labeling
NMR
co-cystalization
- assay design, development and execution
protease
polymerase
dehydrogenase
inhibitor binding
more
- complicate and difficult projects
We guarantee publication quality results. Please email us your project or problems.
We will send you a brief summary and then call you for further discussion.
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