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Custom siRNA Design and Production
Unique approach, better results
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EZBiolab
Setting High Standards for
Scientific Excellence
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Contact Us: service@ezbiolab.com
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RNAi is one of the most important discoveries in biological research in the past 10
years. It provides a powerful tool for gene research and has great potential for
therapeutic application.
The final form for RNAi to block gene expression is a short RNA called siRNA. Its sequence is
complementary to a stretch of its target gene. There are some common features among different siRNA
sequences but no obvious sequence homology can be found. The natural process to produce siRNA in
living cells is controlled by a complicate system. Exogenous siRNA can also be introduced into cells
artificially to specifically silence a gene. EZBiolab provides comprehensive services for design and
production such siRNAs for research use.
EZBiolab RNAi Service
In a laboratory setting, siRNA targeting a specific gene can be delivered into cells in one of the three
forms:
- Chemically synthesized siRNA oligo
- Expression vector carrying shRNA gene that produces siRNA in cells.
- Engeneered Lentiviral particles carrying shRNA gene (vshRNA)
EZBiolab provides service for development and preparation of all three siRNAs. Each of the methods
has its own advantages and disadvantages. Please see the table for comparison.
Like all other services from EZBiolab, we provide high quality RNAi service at the best price in the
industry. For example, our siRNA oligos are all delivered at the highest purity ---- PAGE purified. But
our prices are only about 50% of most others.
Our scientists have been working on RNAi since its infant stage. Over years, we have developed one
of the most advanced siRNA design algorithm. Our unique and powerful TripleStrike siRNA Package
offers the full guarantee ---- if your gene failed to be silenced, we would either send you a re-
designed package or full refund
Triple-Strike Custom siRNA Package
Any Gene, Silence Guaranteed
Total solution
To silence a gene that does not have a known target site, EZBiolab's TripleStrike Custom siRNA
Package provides the best solution. This all-inclusive package provides design and preparation of
three siRNAs targeting three different regions of a gene and all necessary control siRNAs. Customer
only need to provide us a gene accession number (or a sequence). We guarantee that this gene will
be silenced. The package is available for all three forms of siRNA; synthetic RNA oligos, shRNA
vectors and viral shRNAs.
> 98% Knockdown Rate
EZBiolab has designed and prepared hundreds of siRNAs. Our advanced design algorithm is being
constantly refined to incorporate the most updated knowledge in the field. Together with our high
standard for product quality, our TripleStrike package has achieved >98% success rate. Among them:
- all three siRNAs silenced target genes: 28%
- two of three silenced target genes: 56%
- one of three silenced target genes: 18%
In the rare cases (< 2%) that all three siRNAs failed, the major reasons were high GC content or high
homology of the target gene sequence to other genes which resulted non-specific silence.
Full Guarantee
If your gene is failed to be silenced, we will design and make another set of three siRNAs until silence
results are achieved. Alternatively, your can choose full refunded of your order.
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